Analysis across Taiwan Biobank, Biobank Japan and UK Biobank identifies hundreds of novel loci for 36 quantitative traits
Ryan J. Longchamps,
Wei J. Chen,
Posted 15 Apr 2021
medRxiv DOI: 10.1101/2021.04.12.21255236
Posted 15 Apr 2021
Genome-wide association studies (GWAS) have identified tens of thousands of genetic loci associated with human complex traits and diseases. However, the majority of GWAS were conducted in individuals of European ancestry. Failure to capture global genetic diversity has limited biological discovery and impeded equitable delivery of genomic knowledge to diverse populations. Here we report findings from 102,900 individuals across 36 human quantitative traits in the Taiwan Biobank (TWB), a major biobank effort that broadens the population diversity of genetic studies in East Asia (EAS). We identified 979 novel genetic loci, pinpointed novel causal variants through fine-mapping, compared the genetic architecture across TWB, Biobank Japan (BBJ) and UK Biobank (UKBB), and evaluated the utility of cross-phenotype, cross-population polygenic risk scores (PRS) in disease risk prediction. These results demonstrated the potential to advance genomic discovery through increasing and diversifying GWAS populations, and provided insights into the common genetic background for human complex traits in East Asian populations.
- Downloaded 2,478 times
- Download rankings, all-time:
- Site-wide: 9,407
- In genetic and genomic medicine: 54
- Year to date:
- Site-wide: 5,474
- Since beginning of last month:
- Site-wide: 16,017
Downloads over time
Distribution of downloads per paper, site-wide
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!