Rxivist logo

Photoactivatable ('caged') pharmacological agents have revolutionized neuroscience but the palette of available ligands is limited. We describe a general method for caging tertiary amines using an unconventional quaternary ammonium linkage that is chemically stable and elicits a desirable red-shift in activation wavelength. A photoactivatable nicotine (PA-Nic) prepared using this strategy could be uncaged via 1- or 2-photon excitation, making it useful for optopharmacology experiments to study nicotinic acetylcholine receptors (nAChRs) in different experimental preparations and spatiotemporal scales.

Download data

  • Downloaded 825 times
  • Download rankings, all-time:
    • Site-wide: 49,126
    • In neuroscience: 6,466
  • Year to date:
    • Site-wide: 173,640
  • Since beginning of last month:
    • Site-wide: 171,881

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

News