Rxivist logo

In 21,846 eMERGE-III participants, sequencing 10 arrhythmia syndrome disease genes identified 123 individuals with pathogenic or likely pathogenic (P/LP) variants. Compared to non-carriers, P/LP carriers had a significantly higher burden of arrhythmia phenotypes in their electronic health records (EHRs). Fifty one participants had variant results returned. Eighteen of these 51 participants had inherited arrhythmia syndrome diagnoses (primarily long QT syndrome), and 11/18 of these diagnoses were made only after variant results were returned. After in vitro functional evaluation of 50 variants of uncertain significance (VUS), we reclassified 11 variants: 3 to likely benign and 8 to P/LP. As large numbers of people are sequenced, the disease risk from rare variants in arrhythmia genes can be assessed by integrating genomic screening, EHR phenotypes, and in vitro functional studies.

Download data

  • Downloaded 169 times
  • Download rankings, all-time:
    • Site-wide: 123,051
    • In genetic and genomic medicine: 624
  • Year to date:
    • Site-wide: 27,320
  • Since beginning of last month:
    • Site-wide: 28,568

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

News