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A standardized analytics pipeline for reliable and rapid development and validation of prediction models using observational health data

By Sara Khalid, Cynthia Yang, Clair Blacketer, Talita Duarte-Salles, Sergio Fernandez-Bertolin, Chungsoo Kim, Rae Woong Park, Jimyung Park, Martijn Schuemie, Anthony G. Sena, Marc A Suchard, Seng Chan You, Peter Rijnbeek, Jenna M. Reps

Posted 26 Mar 2021
medRxiv DOI: 10.1101/2021.03.23.21254098

Background and Objective: As a response to the ongoing COVID-19 pandemic, several prediction models have been rapidly developed, with the aim of providing evidence-based guidance. However, no COVID-19 prediction model in the existing literature has been found to be reliable. Models are commonly assessed to have a risk of bias, often due to insufficient reporting, use of non-representative data, and lack of large-scale external validation. In this paper, we present the Observational Health Data Sciences and Informatics (OHDSI) analytics pipeline for patient-level prediction as a standardized approach for rapid yet reliable development and validation of prediction models. We demonstrate how our analytics pipeline and open-source software can be used to answer important prediction questions while limiting potential causes of bias (e.g., by validating phenotypes, specifying the target population, performing large-scale external validation and publicly providing all analytical source code). Methods: We show step-by-step how to implement the pipeline for the question: In patients hospitalized with COVID-19, what is the risk of death 0 to 30 days after hospitalization. We develop models using six different machine learning methods in a US claims database containing over 20,000 COVID-19 hospitalizations and externally validate the models using data containing over 45,000 COVID-19 hospitalizations from South Korea, Spain, and the US. Results: Our open-source tools enabled us to efficiently go end-to-end from problem design to reliable model development and evaluation. When predicting death in patients hospitalized for COVID-19 adaBoost, random forest, gradient boosting machine, and decision tree yielded similar or lower internal and external validation discrimination performance compared to L1-regularized logistic regression, whereas the MLP neural network consistently resulted in lower discrimination. L1-regularized logistic regression models were well calibrated. Conclusion: Our results show that following the OHDSI analytics pipeline for patient-level prediction can enable the rapid development towards reliable prediction models. The OHDSI tools and pipeline are open source and available to researchers around the world.

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