Challenges in defining Long COVID: Striking differences across literature, Electronic Health Records, and patient-reported information
Halie M Rando,
Tellen D Bennett,
James Brian Byrd,
Carolyn T Bramante,
Tiffany J Callahan,
Christopher G Chute,
Rachel R Deer,
Farrukh M Koraishy,
Julie A McMurry,
Richard A Moffitt,
Emily R Pfaff,
Peter N. Robinson,
Anthony E Solomonides,
Anupam A Sule,
Melissa A Haendel
Posted 26 Mar 2021
medRxiv DOI: 10.1101/2021.03.20.21253896
Posted 26 Mar 2021
Since late 2019, the novel coronavirus SARS-CoV-2 has introduced a wide array of health challenges globally. In addition to a complex acute presentation that can affect multiple organ systems, increasing evidence points to long-term sequelae being common and impactful. As the worldwide scientific community forges ahead with efforts to characterize a wide range of outcomes associated with SARS-CoV-2 infection, the proliferation of available data has made it clear that formal definitions are needed in order to design robust and consistent studies of Long COVID that consistently capture variation in long-term outcomes. In the present study, we investigate the definitions used in the literature published to date and compare them against data available from electronic health records and patient-reported information collected via surveys. Long COVID holds the potential to produce a second public health crisis on the heels of the pandemic. Proactive efforts to identify the characteristics of this heterogeneous condition are imperative for a rigorous scientific effort to investigate and mitigate this threat.
- Downloaded 2,839 times
- Download rankings, all-time:
- Site-wide: 5,702
- In infectious diseases: 1,037
- Year to date:
- Site-wide: 1,100
- Since beginning of last month:
- Site-wide: 2,963
Downloads over time
Distribution of downloads per paper, site-wide
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!