Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 67,143 bioRxiv papers from 295,399 authors.

Schizophrenia Exhibits Bi-Directional Brain-Wide Alterations in Cortico-Striato-Cerebellar Circuits

By Jie Lisa Ji, Caroline Diehl, Charles Schleifer, Carol A Tamminga, Matcheri S Keshavan, John A Sweeney, Brett A Clementz, S. Kristian Hill, Godfrey Pearlson, Genevieve Yang, Gina Creatura, John Krystal, Grega Repovs, John Murray, Anderson M. Winkler, Alan Anticevic

Posted 24 Jul 2017
bioRxiv DOI: 10.1101/166728 (published DOI: 10.1093/cercor/bhy306)

Distributed neural dysconnectivity is considered a hallmark feature of schizophrenia, yet a tension exists between studies pinpointing focal disruptions versus those implicating brain-wide disturbances. The cerebellum and the striatum communicate reciprocally with the thalamus and cortex through monosynaptic and polysynaptic connections, forming cortico-striatal-thalamic-cerebellar (CSTC) functional pathways that may be sensitive to brain-wide dysconnectivity in schizophrenia. It remains unknown if the same pattern of alterations persists across CSTC systems, or if specific alterations exist along key functional elements of these networks. We characterized connectivity along major functional CSTC subdivisions using resting-state functional magnetic resonance imaging in 159 chronic patients and 162 matched controls. Associative CSTC subdivisions revealed consistent brain-wide bi-directional alterations in patients, marked by hyper-connectivity with sensory-motor cortices and hypo-connectivity with association cortex. Focusing on the cerebellar and striatal components, we validate the effects using data-driven k-means clustering of voxel-wise dysconnectivity and support vector machine classifiers. We replicate these results in an independent sample of 202 controls and 145 patients, additionally demonstrating that these neural effects relate to cognitive performance across subjects. Taken together, these results from complementary approaches implicate a consistent motif of brain-wide alterations in CSTC systems in schizophrenia, calling into question accounts of exclusively focal functional disturbances.

Download data

  • Downloaded 781 times
  • Download rankings, all-time:
    • Site-wide: 11,411 out of 67,143
    • In neuroscience: 1,840 out of 12,032
  • Year to date:
    • Site-wide: 27,474 out of 67,143
  • Since beginning of last month:
    • Site-wide: 42,632 out of 67,143

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News