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Background rates of all-cause mortality, hospitalizations, and emergency department visits among nursing home residents in Ontario, Canada to inform COVID-19 vaccine safety assessments

By Maria Sundaram, Sharifa Nasreen, Andrew Calzavara, Siyi He, Hannah Chung, Susan E Bronskill, Sarah A Buchan, Mina Tadrous, Peter Tanuseputro, Kumanan Wilson, Sarah Wilson, Jeff Kwong, Canadian Immunization Research Network (CIRN) Investigators

Posted 24 Mar 2021
medRxiv DOI: 10.1101/2021.03.17.21253290

Background. Nursing home (NH) residents are prioritized for COVID-19 vaccination. We report monthly mortality, hospitalizations, and emergency department (ED) visit incidence rates (IRs) during 2010-2020 to provide context for COVID-19 vaccine safety assessments. Methods. We observed outcomes among NH residents using administrative databases. IRs were calculated by month, sex, and age group. Comparisons between months were assessed using one-sample t-tests; comparisons by age and sex were assessed using chi-squared tests. Results. From 2010-2019, there were 83,453 (SD: 652.4) NH residents per month, with an average of 2.3 (SD: 0.28) deaths, 3.1 (SD: 0.16) hospitalizations, and 3.6 (SD: 0.17) ED visits per 100 residents per month. From March to December 2020, mortality IRs were increased, but hospitalization and ED visit IRs were reduced (p<0.05). Conclusion. We identified consistent monthly mortality, hospitalization, and ED visit IRs during 2010-2019. Marked differences in these rates were observed during 2020, coinciding with the COVID-19 pandemic. Keywords: long-term care, mortality, hospitalization, baseline rates, COVID-19 vaccine safety

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