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Alternative splicing of OAS1 alters the risk for severe COVID-19

By Jennifer Huffman, Guillaume Butler-Laporte, Atlas Khan, Theodore G. Drivas, Gina M. Peloso, Tomoko Nakanishi, Anurag Verma, Krzysztof Kiryluk, J Brent Richards, Hugo Zeberg

Posted 20 Mar 2021
medRxiv DOI: 10.1101/2021.03.20.21254005

A locus containing OAS1/2/3 has been identified as a risk locus for severe COVID-19 among Europeans ancestry individuals, with a protective haplotype of [~]75 kilobases derived from Neanderthals. Here, we show that among several potentially causal variants at this locus, a splice variant of OAS1 occurs in people of African ancestry independently of the Neanderthal haplotype and confers protection against COVID-19 of a magnitude similar to that seen in individuals without African ancestry.

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