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Membrane proteins with high N-glycosylation, high expression, and multiple interaction partners were preferred by mammalian viruses as receptors

By Zheng Zhang, Zhaozhong Zhu, Wenjun Chen, Zena Cai, Beibei Xu, Zhiying Tan, Aiping Wu, Xingyi Ge, Xinhong Guo, Zhongyang Tan, Zanxian Xia, Haizhen Zhu, Taijiao Jiang, Yousong Peng

Posted 25 Feb 2018
bioRxiv DOI: 10.1101/271171 (published DOI: 10.1093/bioinformatics/bty694)

Receptor mediated entry is the first step for viral infection. However, the relationship between viruses and receptors is still obscure. Here, by manually curating a high-quality database of 268 pairs of mammalian virus-host receptor interaction, which included 128 unique viral species or sub-species and 119 virus receptors, we found the viral receptors were structurally and functionally diverse, yet they had several common features when compared to other cell membrane proteins: more protein domains, higher level of N-glycosylation, higher ratio of self-interaction and more interaction partners, and higher expression in most tissues of the host. Additionally, the receptors used by the same virus tended to co-evolve. Further correlation analysis between viral receptors and the tissue and host specificity of the virus shows that the virus receptor similarity was a significant predictor for mammalian virus cross-species. This work could deepen our understanding towards the viral receptor selection and help evaluate the risk of viral zoonotic diseases.

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