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Modified Oxacillin Resistant Staphylococcus aureus detected in neonatal intensive care patients

By Melissa R. Gitman, Bremy Alburquerque, Adriana Van De Guchte, Mitchell J. Sullivan, Ajay Obla, Jose Polanco, Marilyn Chung, Irina Oussenko, Melissa Laird Smith, Flora Samaroo, Debbie Barackman, Deena R Altman, Emilia M. Sordillo, Harm van Bakel

Posted 09 Mar 2021
medRxiv DOI: 10.1101/2021.03.04.21251785

Active surveillance in our neonatal intensive care unit identified Staphylococcus aureus cultures from two infants with heterogeneity in methicillin resistance between isolated subclones lacking mecA and mecC. Whole-genome analysis of 4 modified (MODSA) and 4 methicillin-susceptible (MSSA) subclones for each culture identified either truncating mutations in the cyclic diadenosine monophosphate phosphodiesterase enzyme (GdpP), or a nonsynonymous substitution in penicillin binding protein 2 (PBP2). These cases highlight the difficulty in identifying non-mecA/non-mecC-mediated methicillin-resistance in clinical laboratories.

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