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Hippocampal signature of associative memory measured by chronic ambulatory intracranial EEG

By Simon Henin, Anita Shankar, Nicolas Hasulak, Daniel Friedman, Patricia Dugan, Lucia Melloni, Adeen Flinker, Cansu Sarac, May Fang, Werner Doyle, Thomas Tcheng, Orrin Devinsky, Lila Davachi, Anli Liu

Posted 30 Mar 2018
bioRxiv DOI: 10.1101/291740 (published DOI: 10.1038/s41598-018-37561-z)

Some patients with medically refractory focal epilepsy are chronically implanted with a brain-responsive neurostimulation device (the RNS System), permitting neurophysiological measurements at millisecond resolution. This clinical device can be adapted to measure hippocampal dynamics time-locked to cognitive tasks. We illustrate the technique with a proof of concept in three patients previously implanted with the RNS System as they engage in an associative memory task, measured months apart. Hippocampal activity measured in successful encoding in RNS System patients mirrors that in surgical patients during intracranial electroencephalography (iEEG), suggesting that chronic iEEG allows sensitive measurements of hippocampal physiology over prolonged timescales.

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