Negligible impact of SARS-CoV-2 variants on CD4+ and CD8+ T cell reactivity in COVID-19 exposed donors and vaccinees.
By
Alison Tarke,
John Sidney,
Nils Methot,
Jennifer M. Dan,
Benjamin Goodwin,
Paul Rubiro,
Aaron Sutherland,
Ricardo da Silva Antunes,
April Frazier,
Stephen A Rawlings,
Davey M Smith,
Bjoern Peters,
Richard H. Scheuermann,
Daniela Weiskopf,
Shane Crotty,
Alba Grifoni,
Alessandro Sette
Posted 01 Mar 2021
bioRxiv DOI: 10.1101/2021.02.27.433180
The emergence of SARS-CoV-2 variants highlighted the need to better understand adaptive immune responses to this virus. It is important to address whether also CD4+ and CD8+ T cell responses are affected, because of the role they play in disease resolution and modulation of COVID-19 disease severity. Here we performed a comprehensive analysis of SARS-CoV-2-specific CD4+ and CD8+ T cell responses from COVID-19 convalescent subjects recognizing the ancestral strain, compared to variant lineages B.1.1.7, B.1.351, P.1, and CAL.20C as well as recipients of the Moderna (mRNA-1273) or Pfizer/BioNTech (BNT162b2) COVID-19 vaccines. Similarly, we demonstrate that the sequences of the vast majority of SARS-CoV-2 T cell epitopes are not affected by the mutations found in the variants analyzed. Overall, the results demonstrate that CD4+ and CD8+ T cell responses in convalescent COVID-19 subjects or COVID-19 mRNA vaccinees are not substantially affected by mutations found in the SARS-CoV-2 variants.
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