Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 67,038 bioRxiv papers from 295,074 authors.

Myelinated inhibitory axons in human neocortex

By Kristina D Micheva, Edward F Chang, Alissa L Nana, William W Seeley, Jonathan T Ting, Charles Cobbs, Ed Lein, Stephen J Smith, Richard J Weinberg, Daniel V Madison

Posted 23 Apr 2018
bioRxiv DOI: 10.1101/306480 (published DOI: 10.1523/ENEURO.0297-18.2018)

Numerous myelinated axons traverse the human neocortex. In a previous paper (Micheva et al., 2016) we showed that in mouse many of these axons belong to local inhibitory neurons, the parvalbumin-positive basket cells. Here, using samples of neurosurgically-excised cortex, we confirm the presence of myelinated inhibitory axons in all layers of human neocortex. As in mouse, these axons have distinctive features, including high neurofilament content, short nodes of Ranvier, and high content of myelin basic protein in their myelin sheath. We further show that, consistent with the known high-energy demands of parvalbumin interneurons, the inhibitory myelinated axons have more mitochondria, as well more 2′,3′-cyclic nucleotide 3′-phosphodiesterase (a protein enriched in the myelin cytoplasmic channels thought to provide access for trophic support from oligodendrocytes). The distinctive features of myelinated inhibitory axons in human cortical grey matter may have important implications for neurological disorders that involve pathologies of myelinated axons.

Download data

  • Downloaded 434 times
  • Download rankings, all-time:
    • Site-wide: 24,751 out of 67,038
    • In neuroscience: 4,244 out of 12,010
  • Year to date:
    • Site-wide: 37,552 out of 67,038
  • Since beginning of last month:
    • Site-wide: 41,047 out of 67,038

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News