Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles
By
Heidi Hautakangas,
Bendik S Winsvold,
Sanni E Ruotsalainen,
Gyda Bjornsdottir,
Aster V.E. Harder,
Lisette J.A. Kogelman,
Laurent F. Thomas,
Raymond Noordam,
Christian Benner,
Padhraig Gormley,
Ville Artto,
Karina Banasik,
Anna Bjornsdottir,
Dorret I Boomsma,
Ben M Brumpton,
Kristoffer Sølvsten Burgdorf,
Julie E Buring,
Mona Ameri Chalmer,
Irene de Boer,
Martin Dichgans,
Christian Erikstrup,
Markus Färkkilä,
Maiken Elvestad Garbrielsen,
Mohsen Ghanbari,
Knut Hagen,
Paavo Häppölä,
Jouke-Jan Hottenga,
Maria G. Hrafnsdottir,
Kristian Hveem,
Marianne Bakke Johnsen,
Mika Kähönen,
Espen S. Kristoffersen,
Tobias Kurth,
Terho Lehtimaki,
Lannie Lighart,
Sigurdur H Magnusson,
Rainer Malik,
Ole Birger Pedersen,
Nadine Pelzer,
Brenda WJH Penninx,
Caroline Ran,
Paul M Ridker,
Frits R Rosendaal,
Gudrun R. Sigurdardottir,
Anne Heidi Skogholt,
Olafur A. Sveinsson,
Thorgeir E. Thorgeirsson,
Henrik Ullum,
Lisanne S Vijfhuizen,
Elisabeth Widén,
Ko Willems van Dijk,
International Headache Genetics Consortium,
HUNT All-in Headache,
Danish Blood Donor Study Genomic Cohort,
Arpo Aromaa,
Andrea Carmine Belin,
Tobias Freilinger,
M. Arfan Ikram,
Marjo-Riitta Järvelin,
Olli Raitakari,
Gisela M Terwindt,
Mikko Kallela,
Maija Wessman,
Jes Olesen,
Daniel I. Chasman,
Dale R Nyholt,
Hreinn Stefánsson,
Kari Stefansson,
Arn MJM van den Maagdenberg,
Thomas Folkmann Hansen,
Samuli Ripatti,
John-Anker Zwart,
Aarno Palotie,
Matti Pirinen
Posted 25 Jan 2021
medRxiv DOI: 10.1101/2021.01.20.21249647
Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. This genome-wide association study (GWAS) of 102,084 migraine cases and 771,257 controls identified 123 loci of which 86 are novel. The loci provide an opportunity to evaluate shared and distinct genetic components in the two main migraine subtypes: migraine with aura and migraine without aura. A stratification of the risk loci using 29,679 cases with subtype information, of which approximately half have never been used in a GWAS before, indicated three risk variants that appear specific for migraine with aura (in HMOX2, CACNA1A and MPPED2), two that appear specific for migraine without aura (near SPINK2 and near FECH), and nine that increase susceptibility for migraine regardless of subtype. The new risk loci include genes encoding recent migraine-specific drug targets, namely calcitonin gene-related peptide (CALCA/CALCB) and serotonin 1F receptor (HTR1F). Overall, genomic annotations among migraine-associated variants were enriched in both vascular and central nervous system tissue/cell types supporting unequivocally that neurovascular mechanisms underlie migraine pathophysiology.
Download data
- Downloaded 506 times
- Download rankings, all-time:
- Site-wide: 59,371
- In genetic and genomic medicine: 239
- Year to date:
- Site-wide: 7,827
- Since beginning of last month:
- Site-wide: 11,202
Altmetric data
Downloads over time
Distribution of downloads per paper, site-wide
PanLingua
News
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!