Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 70,543 bioRxiv papers from 307,989 authors.

Different Brain Networks Underlying Intelligence In Autism Spectrum Disorders And Typically Developing Children

By Emmanuel Peng Kiat Pua, Charles B Malpas, Stephen C Bowden, M. L. Seal

Posted 30 May 2017
bioRxiv DOI: 10.1101/143891 (published DOI: 10.1002/hbm.24074)

Background: There has been sustained clinical and cognitive neuroscience research interest in how network correlates of brain-behaviour relationships might be altered in Autism Spectrum Disorders (ASD) and other neurodevelopmental disorders. As previous work has mostly focused on adults, the nature of whole-brain connectivity networks underlying intelligence in pediatric cohorts with abnormal neurodevelopment requires further investigation. Methods: We used network-based statistics (NBS) to examine the association between resting-state functional Magnetic Resonance Imaging (fMRI) connectivity and fluid intelligence ability in male children (n=50) with Autism Spectrum Disorders (ASD; M=10.45, SD=1.58 years and in controls (M=10.38, SD=0.96 years) matched on fluid intelligence performance, age and sex. Repeat analyses were performed in independent sites for validation and replication. Results: Despite being equivalent on fluid intelligence ability to strictly matched neurotypical controls, boys with ASD displayed a subnetwork of significantly increased associations between functional connectivity and fluid intelligence. Between-group differences remained significant at higher edge thresholding, and results were validated in independent-site replication analyses in an equivalent age and sex-matched cohort with ASD. Regions consistently implicated in atypical connectivity correlates of fluid intelligence in ASD were the angular gyrus, posterior middle temporal gyrus, occipital and temporo-occipital regions. Conclusion: Development of fluid intelligence neural correlates in young ASD males is aberrant, with an increased strength in intrinsic connectivity association during childhood. Alterations in whole-brain network correlates of fluid intelligence in ASD may be a compensatory mechanism that allows equal task performance to neurotypical peers.

Download data

  • Downloaded 641 times
  • Download rankings, all-time:
    • Site-wide: 16,247 out of 70,543
    • In neuroscience: 2,734 out of 12,685
  • Year to date:
    • Site-wide: 25,993 out of 70,543
  • Since beginning of last month:
    • Site-wide: 60,628 out of 70,543

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News