Differential T cell reactivity to seasonal coronaviruses and SARS-CoV-2 in community and health care workers
Ricardo da Silva Antunes,
Yu Dawen Esther,
Stephen A Rawlings,
Jennifer M Dan,
Michael E. Hoffer,
Savita G. Pahwa,
Posted 15 Jan 2021
medRxiv DOI: 10.1101/2021.01.12.21249683
Posted 15 Jan 2021
Herein we measured CD4+ T cell responses against common cold corona (CCC) viruses and SARS-CoV-2 in high-risk health care workers (HCW) and community controls. We observed higher levels of CCC reactive T cells in SARS-CoV-2 seronegative HCW compared to community donors, consistent with potential higher occupational exposure of HCW to CCC. We further show that SARS-CoV-2 reactivity of seronegative HCW was higher than community controls and correlation between CCC and SARS-CoV-2 responses is consistent with cross-reactivity and not associated with recent in vivo activation. Surprisingly, CCC reactivity was decreased in SARS-CoV-2 infected HCW, suggesting that exposure to SARS-CoV-2 might interfere with CCC responses, either directly or indirectly. This result was unexpected, but consistently detected in independent cohorts derived from Miami and San Diego.
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