Parental feeding behaviors are common intervention targets for childhood obesity, but often only deliver small changes. Childhood BMI is partly driven by genetic effects, and the extent to which parental feeding interventions can mediate child genetic liability is not known. Here we aim to examine how potential interventions on parental feeding behaviors can mitigate some of the association between child genetic liability and BMI in early adolescence, using causal inference based methods. Data were from the Avon Longitudinal Study of Parents and Children and we quantified the interventional disparity measure of child genetic risk for BMI (PRS-BMI) on objectively BMI at 12 years, if we were to intervene on parental feeding styles measured when children were 10-11 years (n=4,248). Results are presented as Adjusted Total Association (Adj-Ta) between genetic liability and BMI at 12 years, versus the Interventional Disparity Measure Direct Effect (IDM-DE), which represents the association, that would remain, had we intervened on the parental feeding. For children with the top quintile of genetic liability, an intervention shifting parental feeding to the levels of children with lowest genetic risk, resulted in a difference of 0.81 kg/m2 in BMI at 12y (Adj-Ta= 3.27, 95%CI: 3.04, 3.49; versus IDM-DE=2.46, 95%CI: 2.24, 2.67). Findings suggest that parental feeding interventions have the potential to buffer some of the genetic liability for childhood obesity. Further, we highlight a novel way to analyze potential interventions for health conditions only using secondary data analyses, by combining methodology from statistical genetics and social epidemiology.
- Downloaded 336 times
- Download rankings, all-time:
- Site-wide: 110,989
- In pediatrics: 187
- Year to date:
- Site-wide: 102,517
- Since beginning of last month:
- Site-wide: 38,580
Downloads over time
Distribution of downloads per paper, site-wide
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!