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Genetic correlations between COVID-19 and a variety of diseases and other medically relevant traits

By Xiao Chang, Yun Li, Kenny Nguyen, Huiqi Qu, Yichuan Liu, Joseph Glessner, Patrick M. A. Sleiman, Hakon Hakonarson

Posted 20 Dec 2020
medRxiv DOI: 10.1101/2020.12.18.20248319

We analyzed GWAS results released by COVID-19 Host Genetics Initiative, UK biobank and GWAS Catalog to explore the genetic overlap between COVID-19 and a broad spectrum of traits and diseases. We validate previously reported medical conditions and risk factors based on epidemiological studies, including but not limited to hypertension, type 2 diabetes and obesity. We also report novel traits associated with COVID-19, which have not been previously reported from epidemiological data, such as opioid use and educational attainment. Taken together, this study extends our understanding of the genetic basis of COVID-19, and provides target traits for further epidemiological studies.

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