Case finding of early pregnancies at risk of preeclampsia using maternal blood leptin/ceramide ratio
By
Qianyang Huang,
Shiying Hao,
Jin You,
Xiaoming Yao,
Zhen Li,
James Schilling,
Sheeno Thyparambil,
Wei-li Liao,
Xin Zhou,
Lihong Mo,
Subhashini Ladella,
John C Whitin,
Harvey J Cohen,
Doff B. McElhinney,
Ronald J. Wong,
Gary M. Shaw,
David K. Stevenson,
Karl G Sylvester,
Xuefeng B Ling
Posted 19 Dec 2020
medRxiv DOI: 10.1101/2020.12.17.20248418
The early risk assessment of preeclampsia (PE) remains challenging in current clinical practice. We hypothesized that impending PE events can be predicted, when asymptomatic early in gestation, through the determination of the serum levels of leptin (Lep), a placental functions regulatory cytokine, and ceramide (Cer), a sphingolipid with anti-angiogenic and pro-apoptotic roles. Sera from two independent cohorts of PE and control women were assembled (Testing Cohort: 7 non-PE and 8 PE women sampled at confirmatory diagnoses; Validation Cohort: 20 non-PE and 20 PE women sampled longitudinally through gestation). Our multi-omics approach, integrating global genomic and lipidomic discoveries, revealed a marked elevation of the Lep/Cer (d18:1/25:0) ratio in PE women. Longitudinal analyses of Lep/Cer ratio can predict a median of 23 weeks before PE confirmative diagnosis. Sensitivity, positive predictive value, and AUC of the Lep/Cer (d18:1/25:0) ratio were 85%, 89%, and 0.92. Therefore, serum elevations of Lep/Cer (d18:1/25:0) ratio can be used to assess risk for impending PE during early asymptomatic pregnancies.
Download data
- Downloaded 566 times
- Download rankings, all-time:
- Site-wide: 90,144
- In obstetrics and gynecology: 112
- Year to date:
- Site-wide: 126,784
- Since beginning of last month:
- Site-wide: 193,853
Altmetric data
Downloads over time
Distribution of downloads per paper, site-wide
PanLingua
News
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!