Weight loss response following lifestyle intervention associated with baseline gut metagenomic signature in humans
By
Christian Diener,
Shizhen Qin,
Yong Zhou,
Sushmita Patwardhan,
Li Tang,
Jennifer Lovejoy,
Andrew T. Magis,
Nathan D. Price,
Leroy Hood,
Sean M Gibbons
Posted 05 Jan 2021
bioRxiv DOI: 10.1101/2021.01.05.425474
We report a weight-loss response analysis on a small cohort of individuals (N=25) selected from a larger population (N[~]5,000) enrolled in a commercial scientific wellness program, which included healthy lifestyle coaching. Each individual had baseline data on blood metabolomics, blood proteomics, clinical labs, lifestyle questionnaires, and stool metagenomes. A subset of these participants (N=15) lost at least 10% of their body weight within a 6-12 month period and saw significant improvement in metabolic health markers ( weight loss group), while another subset of individuals (N=10) undergoing the same lifestyle intervention showed no change in BMI over the same timeframe ( no weight loss group). Only a single baseline blood analyte, a metabolite linked to fried food consumption, was (negatively) associated with weight loss, but a large number of baseline stool metagenomic features, including complex polysaccharide and protein degradation genes, stress-response genes, respiration-related genes, cell wall synthesis genes, and gut bacterial replication rates, were significantly associated with weight loss after explicitly controlling for baseline BMI. Together, these results provide a set of baseline gut microbiome functional features that are associated with weight loss outcomes.
Download data
- Downloaded 882 times
- Download rankings, all-time:
- Site-wide: 48,525
- In microbiology: 2,846
- Year to date:
- Site-wide: 130,766
- Since beginning of last month:
- Site-wide: 169,954
Altmetric data
Downloads over time
Distribution of downloads per paper, site-wide
PanLingua
News
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!