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Precision mapping of the mouse brain metabolome

By Huanhuan Pang, Jun-Liszt Li, Xiao-Ling Hu, Fei Chen, Xiaofei Gao, Lauren G. Zacharias, Feng Cai, Ralph J. DeBerardinis, Wenzhi Sun, Zeping Hu, Woo-ping Ge

Posted 29 Dec 2020
bioRxiv DOI: 10.1101/2020.12.28.424544

Metabolism is physiologically fundamental to a biological system. Understanding brain metabolism is critical for our comprehensive knowledge of brain function in health and disease. Combining a microarray collection system with targeted metabolomics analysis, here we performed precision mapping of the metabolome in the mouse brain and created maps for 79 metabolites with a resolution of 0.125mm3 per pixel (i.e., brain subregion). The metabolome atlas provides researchers with a useful resource to interpret the vulnerability of specific brain regions to various disease-relevant metabolic perturbations.

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