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Fucoidan but not 2'-Fucosyllactose could inhibit human norovirus replication in zebrafish larvae

By Malcolm Turk Hsern Tan, Yan Li, Mohamad Eshaghi Gorji, Zhiyuan Gong, Dan Li

Posted 23 Dec 2020
bioRxiv DOI: 10.1101/2020.12.23.424093

Human noroviruses (hNoVs) cause heavy disease burden worldwide and there is no clinically approved vaccination or antivirals hitherto. In this study, with the use of a zebrafish larvae in vivo platform, we investigated the anti-hNoV potentials of fucoidan and 2-Fucosyllactose (2-FL). As a result, although both fucoidan and 2-FL were able to block hNoV GII.4 virus-like particle (VLPs) from binding to type A saliva as expected, only fucoidan but not 2-FL was able to inhibit the replication of hNoV GII.P16-GII.4 in zebrafish larvae, indicating the possible needs of higher molecular weights for fucosylated carbohydrates to exert anti-hNoV effect.

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