Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 57,294 bioRxiv papers from 263,837 authors.

Exploring the limits of network topology estimation using diffusion-based tractography and tracer studies in the macaque cortex

By Kelly Shen, Alexandros Goulas, David Grayson, John Eusebio, Joseph S Gati, Ravi S Menon, Anthony R McIntosh, Stefan Everling

Posted 27 Jun 2018
bioRxiv DOI: 10.1101/356576 (published DOI: 10.1016/j.neuroimage.2019.02.018)

Reconstructing the anatomical pathways of the brain to study the human connectome has become an important endeavour for understanding brain function and dynamics. Reconstruction of the cortico-cortical connectivity matrix in vivo often relies on noninvasive diffusion-weighted imaging (DWI) techniques but the extent to which they can accurately represent the topological characteristics of structural connectomes remains unknown. We explored this question by constructing connectomes using DWI data collected from macaque monkeys in vivo and with data from published invasive tracer studies. We found the strength of fiber tracts was well estimated from DWI and topological properties like degree and modularity were captured by tractography-based connectomes. Rich-club/core-periphery type architecture could also be detected but the classification of hubs using betweenness centrality, participation coefficient and core-periphery identification techniques was inaccurate. Our findings indicate that certain aspects of cortical topology can be faithfully represented in noninvasively-obtained connectomes while other network analytic measures warrant cautionary interpretations.

Download data

  • Downloaded 379 times
  • Download rankings, all-time:
    • Site-wide: 23,750 out of 57,294
    • In neuroscience: 4,014 out of 10,055
  • Year to date:
    • Site-wide: 23,380 out of 57,294
  • Since beginning of last month:
    • Site-wide: 19,847 out of 57,294

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide

Sign up for the Rxivist weekly newsletter! (Click here for more details.)