Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills.
By
Doretta Caramaschi,
Alexander Neumann,
Andres Cardenas,
Gwen Tindula,
Silvia Alemany,
Lea Zillich,
Giancarlo Pesce,
Jari M.T. Lahti,
Alexandra Havdahl,
Rosa Mulder,
Janine F. Felix,
Henning Tiemeier,
Lea Sirignano,
Josef Frank,
Stephanie H. Witt,
Marcella Rietschel,
Michael Deuschle,
Karen Huen,
Brenda Eskenazi,
Tabea Sarah Send,
Muriel Ferrer,
Maria Gilles,
Maria de Agostini,
Nour Baïz,
Sheryl L Rifas-Shiman,
Tuomas Kvist,
Darina Czamara,
Samuli T. Tuominen,
Caroline L Relton,
Dheeraj Rai,
Stephanie J. London,
Katri Räikkönen,
Nina Holland,
Isabella Annesi-Maesano,
Fabian Streit,
Marie-France Hivert,
Emily Oken,
Jordi Sunyer,
Charlotte Cecil,
Gemma Sharp
Posted 20 Dec 2020
bioRxiv DOI: 10.1101/2020.12.18.423421
Cognitive skills are a strong predictor of a wide range of later life outcomes. Genetic and epigenetic associations across the genome explain some of the variation in general cognitive abilities in the general population and it is plausible that epigenetic associations might arise from prenatal environmental exposures and/or genetic variation early in life. We investigated the association between cord blood DNA methylation at birth and cognitive skills assessed in children from eight pregnancy cohorts (N=2196-3798) within the Pregnancy And Childhood Epigenetics (PACE) Consortium across overall, verbal and non-verbal cognitive scores. The associations at single CpG sites were weak for all of the cognitive domains investigated. One region near DUSP22 on chromosome 6 was associated with non-verbal cognition in a model adjusted for maternal IQ. We conclude that there is little evidence to support the idea that cord blood DNA methylation at single CpGs can predict cognitive skills and further studies are needed to confirm regional differences.
Download data
- Downloaded 266 times
- Download rankings, all-time:
- Site-wide: 114,498
- In developmental biology: 3,104
- Year to date:
- Site-wide: 47,687
- Since beginning of last month:
- Site-wide: 41,612
Altmetric data
Downloads over time
Distribution of downloads per paper, site-wide
PanLingua
News
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!