Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 63,093 bioRxiv papers from 279,869 authors.
Shared vulnerability for connectome alterations across psychiatric and neurological brain disorders
Siemon C. de Lange,
Lianne H Scholtens,
Leonard H van den Berg,
Marco P. Boks,
Neeltje E.M. van Haren,
Manon H.J. Hillegers,
María Ángeles Jurado,
Roel A. Ophoff,
Tim J. Reess,
René S. Kahn,
Martijn P. van den Heuvel,
for the Alzheimer’s Disease Neuroimaging Initiative
Posted 03 Jul 2018
bioRxiv DOI: 10.1101/360586 (published DOI: 10.1038/s41562-019-0659-6)
Posted 03 Jul 2018
Macroscale white matter pathways form the infrastructure for large-scale communication in the human brain, a prerequisite for healthy brain function. Conversely, disruptions in the brain's connectivity architecture are thought to play an important role in a wide range of psychiatric and neurological brain disorders. Here we show that especially connections important for global communication and network integration are involved in a wide range of brain disorders. We report on a meta-analytic connectome study comprising in total 895 patients and 1,016 controls across twelve neurological and psychiatric disorders. We extracted disorder connectome fingerprints for each of these twelve disorders, which were then combined into a cross-disorder disconnectivity involvement map, representing the involvement of each brain pathway across brain disorders. Our findings show connections central to the brain's infrastructure are disproportionally involved across a wide range of disorders. Connections critical for global network communication and integration display high disturbance across disorders, suggesting a general cross-disorder involvement and importance of these pathways in normal function. Taken together, our cross-disorder study suggests a convergence of disconnectivity across disorders to a partially shared disconnectivity substrate of central connections.
- Downloaded 591 times
- Download rankings, all-time:
- Site-wide: 15,528 out of 63,093
- In neuroscience: 2,563 out of 11,288
- Year to date:
- Site-wide: 14,609 out of 63,093
- Since beginning of last month:
- Site-wide: 8,299 out of 63,093
Downloads over time
Distribution of downloads per paper, site-wide
- Top preprints of 2018
- Paper search
- Author leaderboards
- Overall metrics
- The API
- Email newsletter
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!