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Persistent Cellular Immunity to SARS-CoV-2 Infection

By Gaelle Breton, Pilar Mendoza, Thomas Hagglof, Thiago Y. Oliveira, Dennis Schaefer-Babajew, Christian Gaebler, Martina Turroja, Arlene Hurley, Marina Caskey, Michel C Nussenzweig

Posted 09 Dec 2020
bioRxiv DOI: 10.1101/2020.12.08.416636

SARS-CoV-2 is responsible for an ongoing pandemic that affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 months after infection from 41 individuals. The data indicate that recovered individuals show persistent polyfunctional SARS-CoV-2 antigen specific memory that could contribute to rapid recall responses. In addition, recovered individuals show enduring immune alterations in relative numbers of CD4+ and CD8+ T cells, expression of activation/exhaustion markers, and cell division.

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