SARS-CoV-2 infection and COVID-19 severity in individuals with prior seasonal coronavirus infection.
Benjamin A. Pinsky,
Posted 07 Dec 2020
medRxiv DOI: 10.1101/2020.12.04.20243741
Posted 07 Dec 2020
A sizable fraction of healthy blood donors have cross-reactive T cells to SARS-CoV-2 peptides due to prior infection with seasonal coronavirus. Understanding the role of cross-reactive T cells in immunity to SARS-CoV-2 has implications for managing the COVID-19 pandemic. We show that individuals with documented history of seasonal coronavirus have a similar SARS-CoV-2 infection rate and COVID-19 severity as those with no prior history of seasonal coronavirus. Our findings suggest prior infection with seasonal coronavirus does not provide immunity to subsequent infection with SARS-CoV-2.
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