Rxivist logo

Immunoglobulin A Antibody Composition Is Sculpted to Bind the Self Gut Microbiome

By Chao Yang, Alice Chen-Liaw, Thomas M Moran, Andrea Cerutti, Jeremiah J Faith

Posted 02 Dec 2020
bioRxiv DOI: 10.1101/2020.11.30.405332

Despite being the most abundantly secreted immunoglobulin isotype, the reactivity of IgA antibodies towards each individual's own gut commensal bacteria still remains elusive. By colonizing germ-free mice with defined commensal bacteria, we found the binding specificity of bulk fecal and serum IgA towards resident gut bacteria resolves well at the species level and has modest strain level specificity. IgA hybridomas generated from lamina propria B cells of gnotobiotic mice showed that most IgA clones recognized a single bacterial species, while a small portion displayed polyreactivity. Species-specific IgAs had a range of strain specificities. Given the unique bacterial species and strain composition in each individual's gut, our findings suggest the IgA repertoire is uniquely shaped to bind our self gut bacteria.

Download data

  • Downloaded 315 times
  • Download rankings, all-time:
    • Site-wide: 102,247
    • In immunology: 3,069
  • Year to date:
    • Site-wide: 43,487
  • Since beginning of last month:
    • Site-wide: 30,483

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

News