Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 63,046 bioRxiv papers from 279,617 authors.

The Feeding Connectome: Convergence of Monosynaptic and Polysynaptic Sensory Paths onto Common Motor Outputs

By Anton Miroschnikow, Philipp Schlegel, Andreas Schoofs, Sebastian Hückesfeld, Feng Li, Casey M. Schneider-Mizell, Richard D. Fetter, James Truman, Albert Cardona, Michael J Pankratz

Posted 13 Jul 2018
bioRxiv DOI: 10.1101/368878 (published DOI: 10.7554/eLife.40247)

Little is known about the organization of central circuits by which external and internal sensory in-puts act on motor outputs to regulate fundamental behaviors such as feeding. We reconstructed, from a whole CNS EM volume, the synaptic map of input and output neurons that underlie food in-take behavior of Drosophila larvae. The input neurons originate from enteric, pharyngeal and external sensory organs and converge onto seven distinct sensory synaptic compartments within the CNS, as defined by distribution patterns of their presynaptic sites. The output neurons consist of pharyngeal motor neurons, serotonergic modulatory neurons, and neuroendocrine neurons that target the ring gland, a key endocrine organ. Monosynaptic connections from a set of sensory synaptic compartments cover the motor and endocrine targets in overlapping domains. Polysynaptic routes can be superimposed on top of the monosynaptic connections, resulting in divergent sensory paths that converge on common motor outputs. A completely different set of sensory compartments is connected to the mushroom body calyx of the memory circuits. Our results illustrate a circuit architecture in which monosynaptic and multisynaptic connections from sensory inputs traverse onto output neurons via a series of converging paths.

Download data

  • Downloaded 656 times
  • Download rankings, all-time:
    • Site-wide: 13,417 out of 63,046
    • In neuroscience: 2,163 out of 11,260
  • Year to date:
    • Site-wide: 32,549 out of 63,046
  • Since beginning of last month:
    • Site-wide: 58,105 out of 63,046

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide

Sign up for the Rxivist weekly newsletter! (Click here for more details.)