Clonal hematopoiesis is associated with risk of severe Covid-19
Kelly L Bolton,
Michael B Foote,
Choong Hyun Sun,
Joon Ho Moon,
Ji Yeon Lee,
Chang Kyung Kang,
Pyoeng Gyun Choe,
Wan Beom Park,
Hong Bin Kim,
Kaitlyn A Tkachuk,
Lior Z. Braunstein,
Melissa S. Pessin,
Luis A. Diaz,
Michael J Rauh,
Mitchell J. Machiela,
Ross L. Levine,
Eu Suk Kim,
Nam Joong Kim,
Posted 27 Nov 2020
medRxiv DOI: 10.1101/2020.11.25.20233163
Posted 27 Nov 2020
Acquired somatic mutations in hematopoietic stem and progenitor cells (clonal hematopoiesis or CH) are associated with advanced age, increased risk of cardiovascular and malignant diseases, and decreased overall survival. These adverse sequelae may be mediated by altered inflammatory profiles observed in patients with CH. A pro-inflammatory immunologic profile is also associated with worse outcomes of certain infections, including SARS-CoV-2 and its associated disease Covid-19. Whether CH predisposes to severe Covid-19 or other infections is unknown. Among 515 individuals with Covid-19 from Memorial Sloan Kettering (MSK) and the Korean Clonal Hematopoiesis (KoCH) consortia, we found that CH was associated with severe Covid-19 outcomes (OR=1.9, 95%=1.2-2.9, p=0.01). We further explored the relationship between CH and risk of other infections in 14,211 solid tumor patients at MSK. CH was significantly associated with risk of Clostridium Difficile (HR=2.0, 95% CI: 1.2-3.3, p=6x10-3) and Streptococcus/Enterococcus infections (HR=1.5, 95% CI=1.1-2.1, p=5x10-3). These findings suggest a relationship between CH and risk of severe infections that warrants further investigation.
- Downloaded 1,425 times
- Download rankings, all-time:
- Site-wide: 16,757
- In infectious diseases: 1,880
- Year to date:
- Site-wide: 4,700
- Since beginning of last month:
- Site-wide: 7,858
Downloads over time
Distribution of downloads per paper, site-wide
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!