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Using Real World Data to Understand HIV and COVID-19 in the U.S.A. and Spain: Characterizing Co-Infected Patients Across the Care Cascade

By Julianna Kohler, Kristin Kostka, Rupa Makadia, Roger Paredes, Talita Duarte-Salles, Scott Duvall, Alison Cheng, Asieh Golozar, Jennifer C. E. Lane, Anthony G. Sena, Peter R. Rijnbeek, Daniel R. Morales, Patrick B. Ryan, Christian Reich, Michael E Matheny, Kristine E Lynch, George K. Siberry, DANIEL PRIETO-ALHAMBRA

Posted 13 Nov 2020
medRxiv DOI: 10.1101/2020.11.10.20229401

ObjectiveMost patients severely affected by COVID-19 have been elderly and patients with underlying chronic disease such as diabetes, cardiovascular disease, or respiratory disease. People living with HIV (PLHIV) may have greater risk of contracting or developing severe COVID-19 due to the underlying HIV infection or higher prevalence of comorbidities. DesignThis is a cohort study, including PLHIV diagnosed, hospitalized, or requiring intensive services for COVID-19. MethodsData sources include routine electronic medical record or claims data from the U.S. and Spain. Patient demographics, comorbidities, and medication history are described. ResultFour data sources had a population of HIV/COVID-19 coinfected patients ranging from 288 to 4606 lives. PLHIV diagnosed with COVID-19 were younger than HIV-negative patients diagnosed with COVID-19. PLHIV diagnosed with COVID-19 diagnosis had similar comorbidities as HIV-negative COVID-19 patients with higher prevalence of those comorbidities and history of severe disease. Treatment regimens were similar between PLHIV diagnosed with COVID-19 or PLHIV requiring intensive services. ConclusionsOur study uses routine practice data to explore HIV impact on COVID-19, providing insight into patient history prior to COVID-19. We found that HIV and COVID-19 coinfected patients have higher prevalence of underlying comorbidities such as cardiovascular and respiratory disease as compared to HIV-negative COVID-19 infected patients. We also found that, across the care cascade, co-infected patients who received intensive services were more likely to have more serious underlying disease or a history of more serious events as compared to PLHIV who were diagnosed with COVID-19.

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