Performance characteristics of a rapid SARS-CoV-2 antigen detection assay at a public plaza testing site in San Francisco
By
Genay O. Pilarowski,
Paul Lebel,
Sara Sunshine,
Jamin Liu,
Emily Crawford,
Carina Marquez,
Luis Rubio,
Gabriel Chamie,
Jackie Martinez,
James Peng,
Douglas Black,
Wesley Wu,
John Pak,
Matthew T Laurie,
Diane Jones,
Steve Miller,
Jon Jacobo,
Susana Rojas,
Susy Rojas,
Robert Nakamura,
Valerie Tulier-Laiwa,
Maya Petersen,
Diane V. Havlir,
The CLIAHUB Consortium,
Joseph DeRisi
Posted 04 Nov 2020
medRxiv DOI: 10.1101/2020.11.02.20223891
We evaluated the performance of the Abbott BinaxNOW Covid-19 rapid antigen test to detect virus among persons, regardless of symptoms, at a public plaza site of ongoing community transmission. Titration with cultured clinical SARS-CoV-2 yielded a human observable threshold between 1.6x104-4.3x104 viral RNA copies (cycle threshold (Ct) of 30.3-28.8 in this assay). Among 878 subjects tested, 3% (26/878) were positive by RT-PCR, of which 15/26 had a Ct<30, indicating high viral load. 40% (6/15) of Ct<30 were asymptomatic. Using this Ct<30 threshold for Binax-CoV2 evaluation, the sensitivity of the Binax-CoV2 was 93.3% (14/15), 95% CI: 68.1-99.8%, and the specificity was 99.9% (855/856), 95% CI: 99.4-99.9%.
Download data
- Downloaded 4,861 times
- Download rankings, all-time:
- Site-wide: 2,946
- In infectious diseases: 727
- Year to date:
- Site-wide: 5,378
- Since beginning of last month:
- Site-wide: 3,105
Altmetric data
Downloads over time
Distribution of downloads per paper, site-wide
PanLingua
News
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!