Transplacental Transfer of SARS-CoV-2 Antibodies
Dustin D. Flannery,
Miren B. Dhudasia,
Madeline R. Pfeifer,
Emily C. Woodford,
Jourdan E. Triebwasser,
Jeffrey S. Gerber,
Jeffrey S Morris,
Madison E. Weirick,
Christopher M. McAllister,
Marcus J Bolton,
Claudia P Arevalo,
Elizabeth M Anderson,
Eileen C. Goodwin,
Scott E. Hensley,
Karen M. Puopolo
Posted 11 Oct 2020
medRxiv DOI: 10.1101/2020.10.07.20207480
Posted 11 Oct 2020
We measured SARS-CoV-2 antibody levels in serum samples from 1,471 mother/newborn dyads and found efficient transplacental transfer of SARS-CoV-2 IgG antibodies in 72 of 83 seropositive pregnant women. Transfer ratios >1.0 were observed among women with an asymptomatic SARS-CoV-2 infection as well as those with mild, moderate and severe COVID-19. Our findings demonstrate the potential for maternally-derived antibodies to provide neonatal protection from SARS-CoV-2 infection.
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