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Absence of SARS-CoV-2 neutralizing activity in pre-pandemic sera from individuals with recent seasonal coronavirus infection

By Daniel Poston, Yiska Weisblum, Helen Wise, Kate Templeton, Sara Jenks, Theodora Hatziioannou, Paul D. Bieniasz

Posted 11 Oct 2020
medRxiv DOI: 10.1101/2020.10.08.20209650

Cross-reactive immune responses elicited by seasonal coronaviruses might impact SARS-CoV-2 susceptibility and disease outcomes. We measured neutralizing activity against SARS-CoV-2 in pre-pandemic sera from patients with prior PCR-confirmed seasonal coronavirus infection. While neutralizing activity against seasonal coronaviruses was detected in nearly all sera, cross-reactive neutralizing activity against SARS-CoV-2 was undetectable.

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