Viral genomes reveal patterns of the SARS-CoV-2 outbreak in Washington State
Nicola Felix Müller,
Chris D. Frazar,
Louise H Moncla,
Victoria M Rachleff,
Nicole AP Lieberman,
Peter D Han,
Thomas R. Sibley,
Caitlin R Wolf,
Janet A Englund,
Barry R. Lutz,
Mark J. Rieder,
Jeffrey S Duchin,
Lea M Starita,
Helen Y. Chu,
Keith R Jerome,
Deborah A. Nickerson,
Posted 30 Sep 2020
medRxiv DOI: 10.1101/2020.09.30.20204230
Posted 30 Sep 2020
The rapid spread of SARS-CoV-2 has gravely impacted societies around the world. Outbreaks in different parts of the globe are shaped by repeated introductions of new lineages and subsequent local transmission of those lineages. Here, we sequenced 3940 SARS-CoV-2 viral genomes from Washington State to characterize how the spread of SARS-CoV-2 in Washington State (USA) was shaped by differences in timing of mitigation strategies across counties, as well as by repeated introductions of viral lineages into the state. Additionally, we show that the increase in frequency of a potentially more transmissible viral variant (614G) over time can potentially be explained by regional mobility differences and multiple introductions of 614G, but not the other variant (614D) into the state. At an individual level, we see evidence of higher viral loads in patients infected with the 614G variant. However, using clinical records data, we do not find any evidence that the 614G variant impacts clinical severity or patient outcomes. Overall, this suggests that at least to date, the behavior of individuals has been more important in shaping the course of the pandemic than changes in the virus.
- Downloaded 986 times
- Download rankings, all-time:
- Site-wide: 26,860
- In epidemiology: 1,552
- Year to date:
- Site-wide: 20,870
- Since beginning of last month:
- Site-wide: 49,173
Downloads over time
Distribution of downloads per paper, site-wide
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!