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Lewis Blood Group Antigens are Associated with Altered Susceptibility to Shigellosis

By Jhansi L Leslie, Erin Weddle, Lauren K. Yum, Ye Lin, Matthew L Jenior, Benjamin Lee, Jennie Z. Ma, Beth D. Kirkpatrick, Uma Nayak, James A Platts-Mills, Herve F. Agaisse, Rashidul Haque, William Petri

Posted 11 Sep 2020
medRxiv DOI: 10.1101/2020.09.09.20191478

In a cohort of infants, we found that lack of the Lewis histo-blood group antigen was associated with increased susceptibility to shigellosis. Broadly inhibiting fucosylation in epithelial cells in vitro decreased invasion by Shigella flexneri. These results support a role for fucosylated glycans in susceptibility to shigellosis.

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