Lewis Blood Group Antigens are Associated with Altered Susceptibility to Shigellosis
By
Jhansi L Leslie,
Erin Weddle,
Lauren K. Yum,
Ye Lin,
Matthew L Jenior,
Benjamin Lee,
Jennie Z. Ma,
Beth D. Kirkpatrick,
Uma Nayak,
James A Platts-Mills,
Herve F. Agaisse,
Rashidul Haque,
William Petri
Posted 11 Sep 2020
medRxiv DOI: 10.1101/2020.09.09.20191478
In a cohort of infants, we found that lack of the Lewis histo-blood group antigen was associated with increased susceptibility to shigellosis. Broadly inhibiting fucosylation in epithelial cells in vitro decreased invasion by Shigella flexneri. These results support a role for fucosylated glycans in susceptibility to shigellosis.
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