Rxivist logo

Lewis Blood Group Antigens are Associated with Altered Susceptibility to Shigellosis

By Jhansi L Leslie, Erin Weddle, Lauren K. Yum, Ye Lin, Matthew L Jenior, Benjamin Lee, Jennie Z. Ma, Beth D. Kirkpatrick, Uma Nayak, James A Platts-Mills, Herve F. Agaisse, Rashidul Haque, William Petri

Posted 11 Sep 2020
medRxiv DOI: 10.1101/2020.09.09.20191478

In a cohort of infants, we found that lack of the Lewis histo-blood group antigen was associated with increased susceptibility to shigellosis. Broadly inhibiting fucosylation in epithelial cells in vitro decreased invasion by Shigella flexneri. These results support a role for fucosylated glycans in susceptibility to shigellosis.

Download data

  • Downloaded 221 times
  • Download rankings, all-time:
    • Site-wide: 182,559
    • In infectious diseases: 7,769
  • Year to date:
    • Site-wide: 160,309
  • Since beginning of last month:
    • Site-wide: 115,974

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

News