Lewis Blood Group Antigens are Associated with Altered Susceptibility to Shigellosis
By
Jhansi L Leslie,
Erin Weddle,
Lauren K. Yum,
Ye Lin,
Matthew L Jenior,
Benjamin Lee,
Jennie Z. Ma,
Beth D. Kirkpatrick,
Uma Nayak,
James A Platts-Mills,
Herve F. Agaisse,
Rashidul Haque,
William A Petri
Posted 11 Sep 2020
medRxiv DOI: 10.1101/2020.09.09.20191478
In a cohort of infants, we found that lack of the Lewis histo-blood group antigen was associated with increased susceptibility to shigellosis. Broadly inhibiting fucosylation in epithelial cells in vitro decreased invasion by Shigella flexneri. These results support a role for fucosylated glycans in susceptibility to shigellosis.
Download data
- Downloaded 139 times
- Download rankings, all-time:
- Site-wide: 147,496
- In infectious diseases: 5,945
- Year to date:
- Site-wide: 114,656
- Since beginning of last month:
- Site-wide: 137,162
Altmetric data
Downloads over time
Distribution of downloads per paper, site-wide
PanLingua
News
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!