Rxivist logo

Functional myeloid-derived suppressor cells expand in blood but not airways of COVID-19 patients and predict disease severity

By Sara Falck-Jones, Sindhu Vangeti, Meng Yu, Ryan Falck-Jones, Alberto Cagigi, Isabella Badolati, Bjorn Osterberg, Maximilian Julius Lautenbach, Eric Ahlberg, Ang Lin, Inga Szurgot, Klara Lenart, Fredrika Hellgren, Jorgen Salde, Jan Albert, Niclas Johansson, Max Bell, Karin Lore, Anna Farnert, Anna Smed-Sorensen

Posted 09 Sep 2020
medRxiv DOI: 10.1101/2020.09.08.20190272

The immunopathology of COVID-19 remains enigmatic, exhibiting immunodysregulation and T cell lymphopenia. Monocytic myeloid-derived suppressor cells (M-MDSC) are T cell suppressors that expand in inflammatory conditions, but their role in acute respiratory infections remains unclear. We studied blood and airways of COVID-19 patients across disease severity at multiple timepoints. M-MDSC frequencies were elevated in blood but not in nasopharyngeal or endotracheal aspirates of COVID-19 patients compared to controls. M-MDSCs isolated from COVID-19 patients suppressed T cell proliferation and IFN{gamma} production partly via an arginase-1 (Arg-1) dependent mechanism. Furthermore, patients showed increased Arg-1 and IL-6 plasma levels. COVID-19 patients had fewer T cells, and displayed downregulated expression of the CD3{zeta} chain. Ordinal regression showed that early M-MDSC frequency predicted subsequent disease severity. In conclusion, M-MDSCs expand in blood of COVID-19 patients, suppress T cells and strongly associate with disease severity, suggesting a role for M-MDSCs in the dysregulated COVID-19 immune response.

Download data

  • Downloaded 888 times
  • Download rankings, all-time:
    • Site-wide: 35,321
    • In infectious diseases: 2,907
  • Year to date:
    • Site-wide: 102,782
  • Since beginning of last month:
    • Site-wide: 62,071

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide