Temporal and Spatial Heterogeneity of Host Response to SARS-CoV-2 Pulmonary Infection
Angela R Shih,
Jonathan H. Chen,
Linda T Nieman,
David J. Lieb,
Anupriya S Kulkarni,
Christopher J Pinto,
Robert B Colvin,
Arthur Y. Kim,
Sarah E Warren,
Jason W Reeves,
Erroll H Rueckert,
Benjamin D. Greenbaum,
Stephen M Lagana,
Miguel N. Rivera,
Lynette M Sholl,
James R. Stone,
David T. Ting,
Posted 02 Aug 2020
medRxiv DOI: 10.1101/2020.07.30.20165241
Posted 02 Aug 2020
The relationship of SARS-CoV-2 lung infection and severity of pulmonary disease is not fully understood. We analyzed autopsy specimens from 24 patients who succumbed to SARS-CoV-2 infection using a combination of different RNA and protein analytical platforms to characterize inter- and intra- patient heterogeneity of pulmonary virus infection. There was a spectrum of high and low virus cases that was associated with duration of disease and activation of interferon pathway genes. Using a digital spatial profiling platform, the virus corresponded to distinct spatial expression of interferon response genes and immune checkpoint genes demonstrating the intra-pulmonary heterogeneity of SARS-CoV-2 infection.
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