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Toward D-Peptide Biosynthesis: Elongation Factor P Enables Ribosomal Incorporation Of Consecutive D-Amino Acids

By Po-Yi Huang, Fanny Wang, Kamesh Narasimhan, Kelly Chatman, John Aach, Sunia A. Trauger, Ryan Spoering, George M Church

Posted 10 Apr 2017
bioRxiv DOI: 10.1101/125930

To maintain stereospecific biochemistry in cells, living organisms have evolved mechanisms to exclude D-amino acids (DAA) in their protein synthesis machinery, which also limits our exploration of the realm of mirror-image molecules. Here, we show that high affinity between EF-Tu and aminoacyl-tRNA promotes D-amino acid incorporation. More strikingly, Elongation Factor P efficiently resolves peptidyl transferase stalling between two consecutive D-amino acids, and hence enables the translation of D-peptides.

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