Rxivist logo

The HSPG Syndecan is a core organizer of cholinergic synapses in C. elegans

By Xin Zhou, Camille Vachon, Melissa Cizeron, Oceane Romatif, Hannes Buelow, Maelle Jospin, Jean-Louis Bessereau

Posted 26 Nov 2020
bioRxiv DOI: 10.1101/2020.11.25.395806

The extracellular matrix has emerged as an active component of chemical synapses regulating synaptic formation, maintenance and homeostasis. The heparan sulfate proteoglycan syndecans are known to regulate cellular and axonal migration in the brain. They are also enriched at synapses, but their synaptic functions remain more elusive. Here we show that SDN-1, the sole ortholog of syndecan in C. elegans, is absolutely required for the synaptic clustering of homomeric 7-like N-acetylcholine receptors (AChR) and regulates the synaptic content of heteromeric L-AChRs. SDN-1 is concentrated at neuromuscular junctions (NMJs) by the neurally-secreted synaptic organizer Ce-Punctin/MADD-4, which also activates the transmembrane netrin receptor DCC. Those cooperatively recruit the FARP and CASK orthologues that localize N-AChRs at cholinergic NMJs through physical interactions. Therefore, SDN-1 stands at the core of the cholinergic synapse organization by bridging the extracellular synaptic determinants to the intracellular synaptic scaffold that controls the postsynaptic receptor content.

Download data

  • Downloaded 180 times
  • Download rankings, all-time:
    • Site-wide: 123,913
    • In neuroscience: 18,834
  • Year to date:
    • Site-wide: 64,488
  • Since beginning of last month:
    • Site-wide: 34,543

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

News