Rxivist logo

Deducing the Dose-response Relation for Coronaviruses from COVID-19, SARS and MERS Meta-analysis Results

By Xiaole Zhang, Jing Wang

Posted 26 Jun 2020
medRxiv DOI: 10.1101/2020.06.26.20140624

The fundamental dose-response relation is still missing for better evaluating and controlling the transmission risk of COVID-19. A recent study by Chu et al. has indicated that the anticipated probability of viral infection is about 12.8% within 1 m and about 2.6% at further distance through a systematic review and meta-analysis. This important information provides us a unique opportunity to assess the dose-response relation of the viruses, if reasonable exposure dose could be estimated. Here we developed a simple framework to integrate the a priori dose-response relation for SARS-CoV based on mice experiments, and the recent data on infection risk and viral shedding, to shed light on the dose-response relation for human. The developed dose-response relation is an exponential function with a constant k in the range of 6.19E4 to 7.28E5 virus copies. The result mean that the infection risk caused by one virus copy in viral shedding is about 1.5E-6 to 1.6E-5. The developed dose-response relation provides a tool to quantify the magnitude of the infection risk.

Download data

  • Downloaded 900 times
  • Download rankings, all-time:
    • Site-wide: 34,720
    • In infectious diseases: 2,894
  • Year to date:
    • Site-wide: 90,899
  • Since beginning of last month:
    • Site-wide: 55,999

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

News