Rxivist logo

Epidemiological description and analysis of RdRp, E and N genes dynamic by RT-PCR of SARS-CoV-2 in Moroccan population: Experience of the National Reference Laboratory (LNR)-UM6SS

By Houda Benrahma, Idrissa Diawara, Imane Smyej, Jalila Rahoui, Nida Meskaouni, Rachid Benmessaoud, Khadija Arouro, Khadija Jaras, Zahra Adam, Salma Nahir, Zineb Aouzal, Hajar Elguazzar, Leila Jeddane, Fadwa Ousti, Jalila Elbakkouri, Chakib Nejjari

Posted 20 Jun 2020
medRxiv DOI: 10.1101/2020.06.18.20135137

The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a new infectious disease that first emerged in Hubei province, China, in December 2019. On 2 March 2020, the Moroccan Ministry of Health confirmed the first COVID-19 case in Morocco. The new virus SARS-CoV-2 was identified in the sample of a Moroccan expatriate residing in Italy. Without a therapeutic vaccine or specific antiviral drugs, early detection and isolation become essential against novel Coronavirus. This study aims to analyze the epidemiological profile of the SARS-CoV-2 in Moroccan cases and to investigate the dynamic of RdRp gene, N gene, and E gene in patients from diagnosis until the recovery. Among 859 Covid-19 RT-PCR tests realized for 285 patients, 133 cases had positive results Covid-19. 9 % of these cases present the 3 genes RdRp, N, and E, 47% only the RdRp gene, 2% with RdRp and N gene, 26% cases are positives with N gene, and 16 % with N and E gene. The analysis of the Covid-19 genes (RdRp, N, and E) dynamic reveal that more than 6% stay positive with detection of the N and E gene, and 14% with the N gene after 12 days of treatment. The median period from positive to the first negative Covid-19 RT-PCR tests was 6.8{+/-}2.24 days for 44% cases, 14.31 {+/-} 2.4 days for 30%, and 22.67 {+/-} 1.21 days for 4%. This a first description of the Moroccan COVID-19 cases and the analysis of the dynamic of the 3 genes RdRp, N, and E. The analysis of our population can help to involved in the care of patients.

Download data

  • Downloaded 45,068 times
  • Download rankings, all-time:
    • Site-wide: 130
    • In infectious diseases: 53
  • Year to date:
    • Site-wide: 24
  • Since beginning of last month:
    • Site-wide: 6

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide