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Identification of multiple large deletions in ORF7a resulting in in-frame gene fusions in clinical SARS-CoV-2 isolates

By Amin Addetia, Hong Xie, Pavitra Roychoudhury, Lasata Shretha, Michelle Loprieno, Meei-Li Huang, Keith Jerome, Alex Greninger

Posted 09 Jun 2020
medRxiv DOI: 10.1101/2020.06.08.20125856

Peculiar among human RNA viruses, coronaviruses have large genomes containing accessory genes that are not required for replication. Numerous mutations within the SARS-CoV-2 genome have been described but few deletions in the accessory genes of SARS-CoV-2 have been reported. Here, we report two large deletions in ORF7a, both of which produce new open reading frames (ORFs) through the fusion of the N-terminus of ORF7a and a downstream ORF.

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