Rxivist logo

Identification of multiple large deletions in ORF7a resulting in in-frame gene fusions in clinical SARS-CoV-2 isolates

By Amin Addetia, Hong Xie, Pavitra Roychoudhury, Lasata Shretha, Michelle Loprieno, Meei-Li Huang, Keith Jerome, Alex Greninger

Posted 09 Jun 2020
medRxiv DOI: 10.1101/2020.06.08.20125856

Peculiar among human RNA viruses, coronaviruses have large genomes containing accessory genes that are not required for replication. Numerous mutations within the SARS-CoV-2 genome have been described but few deletions in the accessory genes of SARS-CoV-2 have been reported. Here, we report two large deletions in ORF7a, both of which produce new open reading frames (ORFs) through the fusion of the N-terminus of ORF7a and a downstream ORF.

Download data

  • Downloaded 648 times
  • Download rankings, all-time:
    • Site-wide: 55,238
    • In infectious diseases: 3,646
  • Year to date:
    • Site-wide: 58,498
  • Since beginning of last month:
    • Site-wide: 75,957

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

News