Effects of adiposity on the human plasma proteome: Observational and Mendelian randomization estimates
Lucy J Goudswaard,
Joshua A Bell,
David A Hughes,
Laura J Corbin,
George Davey Smith,
Emanuele Di Angelantonio,
Willem H Ouwehand,
Nicholas A Watkins,
David J. Roberts,
Adam S. Butterworth,
Nicholas J. Timpson
Posted 02 Jun 2020
medRxiv DOI: 10.1101/2020.06.01.20119081
Posted 02 Jun 2020
Variation in adiposity is associated with cardiometabolic disease outcomes, but the mechanisms leading from this exposure to disease are unclear. This study aimed to estimate effects of adiposity, proxied by body mass index (BMI), on 3,622 unique plasma proteins measured by the SomaLogic platform in 2,737 healthy participants from the INTERVAL study of UK blood donors. We conducted both observational and Mendelian randomization analyses where we used a genetic risk score for BMI as an instrument to estimate effects of BMI on protein levels. Our results suggest that BMI has a broad impact on the human plasma proteome, with estimated effects of BMI appearing strongest on proteins including circulating leptin, sex hormone-binding globulin and fatty acid-binding protein-4. We also provide evidence that proteins most altered by BMI are enriched for genes involved in cardiovascular disease. Altogether, these results help to focus attention onto new potential proteomic signatures of obesity-related disease.
- Downloaded 213 times
- Download rankings, all-time:
- Site-wide: 99,311
- In epidemiology: 4,042
- Year to date:
- Site-wide: 27,829
- Since beginning of last month:
- Site-wide: 56,102
Downloads over time
Distribution of downloads per paper, site-wide
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!