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A serological assay to detect SARS-CoV-2 antibodies in at-home collected finger-prick dried blood spots

By Donna Grace Karp, Kenneth Danh, David Seftel, Peter Robinson, Cheng-ting Tsai

Posted 30 May 2020
medRxiv DOI: 10.1101/2020.05.29.20116004

Accurate surveillance of coronavirus disease 2019 (COVID-19) incidence requires large-scale testing of the population. Current testing methods require in-person collection of biospecimens by a healthcare worker, limiting access of individuals who do not have access to testing facilities while placing both the patient and healthcare worker at risk of exposure to infection. We report the development and validation of a at-home finger-prick dried blood spot collection kit and an analysis method. We demonstrated 100% sensitivity and specificity using at-home collected specimens across the US. Such methods may facilitate the conduct of unbiased serosurveys within hard to reach populations and help reduce the sample collection burden of serological testing on both health care systems and individuals alike.

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