SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood from the San Francisco Bay Area
Sagar P. Bapat,
Claudia Sanchez-San Martin,
Dustin R. Glasner,
Lucy M Han,
David N. Nguyen,
Yale A Santos,
Nancy K Hills,
Chuanyi M Lu,
Jeffrey D. Whitman,
Michael Paul Busch,
Charles Y Chiu
Posted 25 May 2020
medRxiv DOI: 10.1101/2020.05.19.20107482
Posted 25 May 2020
We report very low SARS-CoV-2 seroprevalence in two San Francisco Bay Area populations. Seropositivity was 0.26% in 387 hospitalized patients admitted for non-respiratory indications and 0.1% in 1,000 blood donors. We additionally describe the longitudinal dynamics of immunoglobulin-G, immunoglobulin-M, and in vitro neutralizing antibody titers in COVID-19 patients. Neutralizing antibodies rise in tandem with immunoglobulin levels following symptom onset, exhibiting median time to seroconversion within one day of each other, and there is >93% positive percent agreement between detection of immunoglobulin-G and neutralizing titers.
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