A prospective cohort study of prodromal Alzheimer's disease: Prospective Imaging Study of Ageing: Genes, Brain and Behaviour (PISA)
By
Michelle Lupton,
Gail A Robinson,
Robert J Adam,
Stephen Rose,
Gerard J Byrne,
Olivier Salvado,
Nancy A Pachana,
Osvaldo P Almeida,
Kerrie McAloney,
Scott D. Gordon,
Parnesh Raniga,
Amir Fazlollahi,
Ying Xia,
Amelia Ceslis,
Saurabh Sonkusare,
Qing Zhang,
Mahnoosh Kholghi,
Mohan Karunanithi,
Philip E. Mosley,
Jinglei Lv,
Jessica Adsett,
Natalie Garden,
Jurgen Fripp,
Nicolas G Martin,
Christine C Guo,
Micheal Breakspear
Posted 08 May 2020
medRxiv DOI: 10.1101/2020.05.04.20091140
This prospective cohort study, Prospective Imaging Study of Ageing: "Genes, Brain and Behaviour" (PISA) seeks to characterise the phenotype and natural history of healthy adult Australians at high future risk of Alzheimer's disease (AD). In particular, we are recruiting mid-life Australians with high and low genetic risk of dementia to discover biological markers of early neuropathology, identify modifiable risk factors, and establish the very earliest phenotypic and neuronal signs of disease onset. PISA utilises genetic prediction to recruit and enrich a prospective cohort and follow them longitudinally. Online surveys and cognitive testing are used to characterise an Australia-wide sample currently totalling nearly 3,000 participants. Participants from a defined at-risk cohort and positive controls (clinical cohort of patients with mild cognitive impairment or early AD) are invited for onsite visits for lifestyle monitoring, detailed neurocognitive testing, blood sample donation, plus functional, structural and molecular neuroimaging. This paper describes recruitment of the PISA cohort, study methodology and baseline demographics.
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