Self-reported symptoms of covid-19 including symptoms most predictive of SARS-CoV-2 infection, are heritable
Frances MK Williams,
Ruth C. E. Bowyer,
Caroline I. Le Roy,
Timothy D Spector
Posted 24 Apr 2020
medRxiv DOI: 10.1101/2020.04.22.20072124
Posted 24 Apr 2020
Susceptibility to infection such as SARS-CoV-2 may be influenced by host genotype. TwinsUK volunteers (n=2633) completing the C-19 Covid symptom tracker app allowed classical twin studies of covid-19 symptoms including predicted covid-19, a symptom-based algorithm predicting true infection derived in app users tested for SARS-CoV-2. We found heritability for fever = 41 (95% confidence intervals 12-70)%; anosmia 47 (27-67)%; delirium 49 (24-75)%; and predicted covid-19 gave heritability = 50 (29-70)%.
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