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Self-reported symptoms of covid-19 including symptoms most predictive of SARS-CoV-2 infection, are heritable

By Frances MK Williams, Maxim Freidin, Massimo Mangino, Simon Couvreur, Alessia Visconti, Ruth C. E. Bowyer, Caroline I. Le Roy, Mario Falchi, Carole Sudre, Richard Davies, Christopher Hammond, Cristina Menni, Claire Steves, Timothy D Spector

Posted 24 Apr 2020
medRxiv DOI: 10.1101/2020.04.22.20072124

Susceptibility to infection such as SARS-CoV-2 may be influenced by host genotype. TwinsUK volunteers (n=2633) completing the C-19 Covid symptom tracker app allowed classical twin studies of covid-19 symptoms including predicted covid-19, a symptom-based algorithm predicting true infection derived in app users tested for SARS-CoV-2. We found heritability for fever = 41 (95% confidence intervals 12-70)%; anosmia 47 (27-67)%; delirium 49 (24-75)%; and predicted covid-19 gave heritability = 50 (29-70)%.

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