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Self-reported symptoms of covid-19 including symptoms most predictive of SARS-CoV-2 infection, are heritable

By Frances MK Williams, Maxim Freidin, Massimo Mangino, Simon Couvreur, Alessia Visconti, Ruth C. Bowyer, Caroline I. Le Roy, Mario Falchi, Carole H Sudre, Richard Davies, Christopher Hammond, Cristina Menni, Claire J Steves, Timothy Spector

Posted 24 Apr 2020
medRxiv DOI: 10.1101/2020.04.22.20072124

Susceptibility to infection such as SARS-CoV-2 may be influenced by host genotype. TwinsUK volunteers (n=2633) completing the C-19 Covid symptom tracker app allowed classical twin studies of covid-19 symptoms including predicted covid-19, a symptom-based algorithm predicting true infection derived in app users tested for SARS-CoV-2. We found heritability for fever = 41 (95% confidence intervals 12-70)%; anosmia 47 (27-67)%; delirium 49 (24-75)%; and predicted covid-19 gave heritability = 50 (29-70)%.

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