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The phenotypic changes of γδ T cells in COVID-19 patients

By Lei Lei, Hongbo Qian, Xiaofang Yang, Xiaobo Zhou, Xingzhe Zhang, Dan Zhang, Tongxin Dai, Rui Guo, Lin Shi, Yanbin Cheng, Baojun Zhang, Jinsong Hu, Yaling Guo

Posted 07 Apr 2020
medRxiv DOI: 10.1101/2020.04.05.20046433

A novel pneumonia-associated respiratory syndrome named coronavirus disease-2019 (COVID-19), which caused by SARS-CoV-2 and broken in Wuhan, China in the end of 2019. Unfortunately, there is no specific antiviral agent or vaccine available to treat SARS-CoV-2 infections. Also, information regarding the immunological characteristics in COVID-19 patients remains limited. Here we collected the blood samples from 18 healthy donors (HD) and 38 COVID-19 patients to analyze changes in {gamma}{delta} T cells. In comparison to HD, the {gamma}{delta} T cells percentage was decreased. {gamma}{delta} T cells are able to immediately respond to SARS-CoV-2 infection and upregulate the activation marker CD25. In addition, the increased expression of CD4 in {gamma}{delta} T cells may serve as a biomarker for the assessment of SARS-CoV-2 infection.

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