Coast-to-coast spread of SARS-CoV-2 in the United States revealed by genomic epidemiology
Joseph R Fauver,
Mary E. Petrone,
Emma B Hodcroft,
Hanna Y. Ehrlich,
Alexander G Watts,
Chantal B.F. Vogels,
Anderson F Brito,
Nagarjuna R Cheemarla,
Anne L. Wyllie,
Chaney C Kalinich,
Nicholas James Loman,
Alexander L. Greninger,
Keith R Jerome,
Virginia E. Pitzer,
Saad B. Omer,
Isaac I. Bogoch,
Richard A. Martinello,
Ellen F Foxman,
Marie L. Landry,
Richard A Neher,
Nathan D. Grubaugh
Posted 26 Mar 2020
medRxiv DOI: 10.1101/2020.03.25.20043828
Posted 26 Mar 2020
Since its emergence and detection in Wuhan, China in late 2019, the novel coronavirus SARS-CoV-2 has spread to nearly every country around the world, resulting in hundreds of thousands of infections to date. The virus was first detected in the Pacific Northwest region of the United States in January, 2020, with subsequent COVID-19 outbreaks detected in all 50 states by early March. To uncover the sources of SARS-CoV-2 introductions and patterns of spread within the U.S., we sequenced nine viral genomes from early reported COVID-19 patients in Connecticut. Our phylogenetic analysis places the majority of these genomes with viruses sequenced from Washington state. By coupling our genomic data with domestic and international travel patterns, we show that early SARS-CoV-2 transmission in Connecticut was likely driven by domestic introductions. Moreover, the risk of domestic importation to Connecticut exceeded that of international importation by mid-March regardless of our estimated impacts of federal travel restrictions. This study provides evidence for widespread, sustained transmission of SARS-CoV-2 within the U.S. and highlights the critical need for local surveillance.
- Downloaded 8,547 times
- Download rankings, all-time:
- Site-wide: 1,688
- In public and global health: 66
- Year to date:
- Site-wide: 16,669
- Since beginning of last month:
- Site-wide: 24,711
Downloads over time
Distribution of downloads per paper, site-wide
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!